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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1h1r 6CP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1h1r 6CPCyclin-dependent kinase 2 2.7.11.22 0.893
1h1q 2A6Cyclin-dependent kinase 2 2.7.11.22 0.762
1h1s 4SPCyclin-dependent kinase 2 2.7.11.22 0.754
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1oi9 N20Cyclin-dependent kinase 2 2.7.11.22 0.734
1oiu N76Cyclin-dependent kinase 2 2.7.11.22 0.731
2iw8 4SPCyclin-dependent kinase 2 2.7.11.22 0.727
1ogu ST8Cyclin-dependent kinase 2 2.7.11.22 0.707
4eor 4SPCyclin-dependent kinase 2 2.7.11.22 0.706
1oiy N41Cyclin-dependent kinase 2 2.7.11.22 0.699
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.679
2iw9 4SPCyclin-dependent kinase 2 2.7.11.22 0.675
4eok 4SPCyclin-dependent kinase 2 2.7.11.22 0.670
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.665
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.662
3rkb 12ZCyclin-dependent kinase 2 2.7.11.22 0.660
4e5f 0N7Polymerase acidic protein / 0.660
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.652
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.652
3sqq 99ZCyclin-dependent kinase 2 2.7.11.22 0.650