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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gij 2PU Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1gij 2PUCyclin-dependent kinase 2 2.7.11.22 0.913
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.674
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.667
1oec AA2Fibroblast growth factor receptor 2 / 0.663
3i4b Z48Glycogen synthase kinase-3 beta 2.7.11.26 0.660
4e5f 0N7Polymerase acidic protein / 0.660
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.659
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.659
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.656
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.654
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.654
1pxk CK3Cyclin-dependent kinase 2 2.7.11.22 0.651