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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1fin ATP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.808
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.691
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.690
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.687
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.681
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.677
1gz8 MBPCyclin-dependent kinase 2 2.7.11.22 0.676
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.676
4xhg ADPUncharacterized protein / 0.675
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.671
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.669
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.666
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.666
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.666
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.665
1zyd ATPeIF-2-alpha kinase GCN2 / 0.664
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.663
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.662
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.662
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.662
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.661
1n2v BDIQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.658
4fkl CK2Cyclin-dependent kinase 2 2.7.11.22 0.658
3q5i ANPProtein kinase, putative / 0.657
2pup ADPMethylthioribose kinase 2.7.1.100 0.655
3tei ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.655
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.653
1u54 ACPActivated CDC42 kinase 1 / 0.653
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.653
1w8c N69Cyclin-dependent kinase 2 2.7.11.22 0.652
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.651
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.651