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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1f28 F89 Thymidylate synthase 2.1.1.45

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1f28 F89Thymidylate synthase 2.1.1.45 1.091
1syn F89Thymidylate synthase / 0.746
4y8v ADPAcyl-CoA synthetase (NDP forming) / 0.744
1sej F89Bifunctional dihydrofolate reductase-thymidylate synthase / 0.660
1tsd F89Thymidylate synthase / 0.656