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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ez0 NAP NADP-dependent fatty aldehyde dehydrogenase 1.2.1.4

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 1.233
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.985
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.797
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.775
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.770
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.764
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.764
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.753
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.750
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.734
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.725
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.703
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.702
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.686
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.680
3b4w NADAldehyde dehydrogenase family protein / 0.677
4oqy NDP(S)-imine reductase / 0.676
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.673
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.668
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.666
2jah NDPClavaldehyde dehydrogenase / 0.665
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.663
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.661
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.661
4a5l NDPThioredoxin reductase / 0.661
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.660
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.660
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.659
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.659
4i8q NADPutative betaine aldehyde dehyrogenase / 0.658
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.657
4pz2 NADAldehyde dehydrogenase 2-6 / 0.657
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.657
3ean NAPThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.656
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.655
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.653
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.651