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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1eqg IBP Prostaglandin G/H synthase 1 1.14.99.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1eqg IBPProstaglandin G/H synthase 1 1.14.99.1 1.054
1eqh FLPProstaglandin G/H synthase 1 1.14.99.1 0.871
3n8z FLPProstaglandin G/H synthase 1 1.14.99.1 0.856
2ayl FLPProstaglandin G/H synthase 1 1.14.99.1 0.854
3n8w FLPProstaglandin G/H synthase 1 1.14.99.1 0.852
1ht8 34CProstaglandin G/H synthase 1 1.14.99.1 0.836
1q4g BFLProstaglandin G/H synthase 1 1.14.99.1 0.830
4ph9 IBPProstaglandin G/H synthase 2 1.14.99.1 0.796
1ht5 FL2Prostaglandin G/H synthase 1 1.14.99.1 0.774
3rr3 FLRProstaglandin G/H synthase 2 1.14.99.1 0.745
4fm5 DF0Prostaglandin G/H synthase 2 1.14.99.1 0.707
3pgh FLPProstaglandin G/H synthase 2 1.14.99.1 0.685
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.673
3zp4 TSAChorismate mutase AroH 5.4.99.5 0.669
3fbc TYDNucleoside diphosphate kinase 2.7.4.6 0.660
3o5t ADPNitrogen regulatory protein P-II 1 / 0.655
1ori SAHProtein arginine N-methyltransferase 1 / 0.653
1p3d UMAUDP-N-acetylmuramate--L-alanine ligase 6.3.2.8 0.651
3q7d NPXProstaglandin G/H synthase 2 1.14.99.1 0.650
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.650
4khy TTPDNA-directed DNA polymerase / 0.650