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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dyr TOP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dyr TOPDihydrofolate reductase 1.5.1.3 0.995
3tq8 TOPDihydrofolate reductase / 0.826
1dg5 TOPDihydrofolate reductase 1.5.1.3 0.733
2w3v TOPDihydrofolate reductase / 0.727
4g8z TOPDihydrofolate reductase 1.5.1.3 0.715
4m7v RARDihydrofolate reductase / 0.706
3m09 RARDihydrofolate reductase 1.5.1.3 0.702
3fyv XCFDihydrofolate reductase 1.5.1.3 0.700
2hm9 TRRDihydrofolate reductase 1.5.1.3 0.697
4h96 14QDihydrofolate reductase 1.5.1.3 0.694
4ddr MMVDihydrofolate reductase 1.5.1.3 0.687
3frf XCFDihydrofolate reductase 1.5.1.3 0.684
4elb 34SDihydrofolate reductase / 0.680
4elh 53IDihydrofolate reductase / 0.677
2w9h TOPDihydrofolate reductase 1.5.1.3 0.675
1dra MTXDihydrofolate reductase 1.5.1.3 0.674
4dfr MTXDihydrofolate reductase 1.5.1.3 0.662
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.661
4qi9 MTXDihydrofolate reductase / 0.661
3fre TOPDihydrofolate reductase 1.5.1.3 0.659
1mvt DTMDihydrofolate reductase 1.5.1.3 0.657
3drc MTXDihydrofolate reductase 1.5.1.3 0.657
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.652
1hfr MOTDihydrofolate reductase 1.5.1.3 0.651
3fy8 XCFDihydrofolate reductase 1.5.1.3 0.651
3fyw XCFDihydrofolate reductase 1.5.1.3 0.651