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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dlr MXA Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dlr MXADihydrofolate reductase 1.5.1.3 1.012
4y8v ADPAcyl-CoA synthetase (NDP forming) / 0.744
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.703
1s3u TQDDihydrofolate reductase 1.5.1.3 0.702
1kms LIHDihydrofolate reductase 1.5.1.3 0.701
3gyf 51PDihydrofolate reductase 1.5.1.3 0.673
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.653
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.653