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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dhf FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dhf FOLDihydrofolate reductase 1.5.1.3 0.945
4keb FOLDihydrofolate reductase 1.5.1.3 0.900
4m6k FOLDihydrofolate reductase 1.5.1.3 0.884
2w3m FOLDihydrofolate reductase 1.5.1.3 0.873
4kfj FOLDihydrofolate reductase 1.5.1.3 0.865
1hfq MOTDihydrofolate reductase 1.5.1.3 0.830
3ghw GHWDihydrofolate reductase 1.5.1.3 0.829
4x5f FOLDihydrofolate reductase 1.5.1.3 0.810
1drf FOLDihydrofolate reductase 1.5.1.3 0.788
1hfp MOTDihydrofolate reductase 1.5.1.3 0.788
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.788
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.786
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.785
4x5g FOLDihydrofolate reductase 1.5.1.3 0.784
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.781
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.781
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.774
4i13 FOLDihydrofolate reductase 1.5.1.3 0.772
4x5h FOLDihydrofolate reductase 1.5.1.3 0.772
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.771
4i1n FOLDihydrofolate reductase 1.5.1.3 0.770
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.770
2dhf DZFDihydrofolate reductase 1.5.1.3 0.768
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.767
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.767
4x5i FOLDihydrofolate reductase 1.5.1.3 0.766
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.765
2d0k FOLDihydrofolate reductase 1.5.1.3 0.762
3eig MTXDihydrofolate reductase 1.5.1.3 0.758
4kjj FOLDihydrofolate reductase 1.5.1.3 0.758
4m6l 21VDihydrofolate reductase 1.5.1.3 0.755
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.752
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.750
1dyi FOLDihydrofolate reductase 1.5.1.3 0.747
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.744
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.741
4fhb FOLDihydrofolate reductase 1.5.1.3 0.738
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.737
2zza FOLDihydrofolate reductase / 0.734
1dls MTXDihydrofolate reductase 1.5.1.3 0.731
1ohj COPDihydrofolate reductase 1.5.1.3 0.731
3ia4 MTXDihydrofolate reductase / 0.729
1dyh DZFDihydrofolate reductase 1.5.1.3 0.726
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.726
7dfr FOLDihydrofolate reductase 1.5.1.3 0.726
3ghv GHCDihydrofolate reductase 1.5.1.3 0.725
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.725
1re7 FOLDihydrofolate reductase 1.5.1.3 0.724
3frd DHFDihydrofolate reductase 1.5.1.3 0.722
1hfr MOTDihydrofolate reductase 1.5.1.3 0.717
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.717
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.716
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.712
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.711
2drc MTXDihydrofolate reductase 1.5.1.3 0.711
3tq9 MTXDihydrofolate reductase / 0.709
1ohk COPDihydrofolate reductase 1.5.1.3 0.708
3tqb FOLDihydrofolate reductase / 0.708
1u72 MTXDihydrofolate reductase 1.5.1.3 0.707
4qi9 MTXDihydrofolate reductase / 0.707
3och 2MXDihydrofolate reductase 1.5.1.3 0.706
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.706
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.705
5ccc DDFDihydrofolate reductase 1.5.1.3 0.705
1e26 GPBDihydrofolate reductase 1.5.1.3 0.702
2qk8 MTXDihydrofolate reductase / 0.701
1drb MTXDihydrofolate reductase 1.5.1.3 0.700
1dra MTXDihydrofolate reductase 1.5.1.3 0.698
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.698
1dhi MTXDihydrofolate reductase 1.5.1.3 0.696
1dyj DDFDihydrofolate reductase 1.5.1.3 0.696
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.694
3drc MTXDihydrofolate reductase 1.5.1.3 0.693
5hi6 MTXDihydrofolate reductase / 0.690
1dhj MTXDihydrofolate reductase 1.5.1.3 0.688
4dfr MTXDihydrofolate reductase 1.5.1.3 0.688
4p66 MTXDihydrofolate reductase / 0.687
1dre MTXDihydrofolate reductase 1.5.1.3 0.686
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.682
4p68 MTXDihydrofolate reductase / 0.682
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.680
1tdr MTXDihydrofolate reductase 1.5.1.3 0.680
1jom FFODihydrofolate reductase 1.5.1.3 0.679
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.676
1ddr MTXDihydrofolate reductase 1.5.1.3 0.671
1df7 MTXDihydrofolate reductase 1.5.1.3 0.666
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.666
1u70 MTXDihydrofolate reductase 1.5.1.3 0.663
1rby KEUTrifunctional purine biosynthetic protein adenosine-3 2.1.2.2 0.660
3dau MTXDihydrofolate reductase 1.5.1.3 0.660
2g1m 4HGEgl nine homolog 1 / 0.657
1rc0 KT5Trifunctional purine biosynthetic protein adenosine-3 2.1.2.2 0.655
3dfr MTXDihydrofolate reductase 1.5.1.3 0.654
1w06 W05Isopenicillin N synthase 1.21.3.1 0.653
2p1o NLAProtein TRANSPORT INHIBITOR RESPONSE 1 / 0.653
3nxo D2BDihydrofolate reductase 1.5.1.3 0.653
3sxj SAMPutative methyltransferase / 0.653
1qjf ACSIsopenicillin N synthase 1.21.3.1 0.652
1toi HCIAspartate aminotransferase 2.6.1.1 0.651
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.651
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.650
4ew2 DXYTrifunctional purine biosynthetic protein adenosine-3 2.1.2.2 0.650