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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1bwl FMN NADPH dehydrogenase 1 1.6.99.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 1.212
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 1.098
1oya FMNNADPH dehydrogenase 1 1.6.99.1 1.076
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 1.038
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 1.035
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 1.033
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.993
4tmc FMNOld yellow enzyme / 0.992
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.984
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.978
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.973
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.966
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.965
2h8x FMNXenA / 0.961
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.956
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.956
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.951
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.949
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.934
4tmb FMNOld yellow enzyme / 0.924
4utm FNRXenobiotic reductase / 0.913
3tjl FMNNADPH dehydrogenase / 0.904
3atz FMNProstaglandin F2a synthase / 0.896
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.895
4uth FMNXenobiotic reductase / 0.895
3p8i FMNPentaerythritol tetranitrate reductase / 0.894
3l67 FMNXenobiotic reductase / 0.893
3l5l FMNXenobiotic reductase / 0.891
3p74 FMNPentaerythritol tetranitrate reductase / 0.891
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.890
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.890
4jic FMNGTN Reductase / 0.890
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.888
1h50 FMNPentaerythritol tetranitrate reductase / 0.885
4df2 FMNNADPH dehydrogenase / 0.884
2abb FMNPentaerythritol tetranitrate reductase / 0.878
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.869
4e2b FMNDehydrogenase / 0.866
1h51 FMNPentaerythritol tetranitrate reductase / 0.865
3gka FMNN-ethylmaleimide reductase / 0.862
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.859
3f03 FMNPentaerythritol tetranitrate reductase / 0.858
3aty FMNProstaglandin F2a synthase / 0.852
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.849
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.849
1gwj FMNMorphinone reductase / 0.848
4utl FNRXenobiotic reductase / 0.847
4qai FMNNADPH dehydrogenase / 0.841
4e2d FMNDehydrogenase / 0.835
3p67 FMNPentaerythritol tetranitrate reductase / 0.833
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.830
1h63 FMNPentaerythritol tetranitrate reductase / 0.818
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.818
3p84 FMNPentaerythritol tetranitrate reductase / 0.814
1vhn FMNtRNA-dihydrouridine synthase / 0.813
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.811
3n19 FNRXenobiotic reductase / 0.808
4utk FNRXenobiotic reductase / 0.807
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.805
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.799
1z41 FMNNADPH dehydrogenase / 0.798
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.795
5cpm FNRNADH:flavin oxidoreductase / 0.793
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.749
3p82 FMNPentaerythritol tetranitrate reductase / 0.744
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.739
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.739
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.736
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.733
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.729
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.724
5ebu FMNLactate oxidase / 0.723
3hf3 FMNChromate reductase / 0.721
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.720
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.718
1vyr FMNPentaerythritol tetranitrate reductase / 0.716
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.712
2nli FMNLactate oxidase / 0.710
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.708
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.706
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.705
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.702
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.699
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.698
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.695
3p8j FMNPentaerythritol tetranitrate reductase / 0.694
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.693
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.692
2zfa FMNLactate oxidase / 0.690
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.690
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.688
3gr8 FMNNADPH dehydrogenase / 0.687
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.687
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.683
3esz FMNFlavodoxin / 0.683
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.682
3mdd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.681
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.679
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.679
2j6x FMNLactate oxidase / 0.678
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.676
4bby FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.674
1akr FMNFlavodoxin / 0.672
4yco FMNtRNA-dihydrouridine(16) synthase / 0.672
3w77 FMNFMN-dependent NADH-azoreductase / 0.671
4yl2 FMNLactate oxidase / 0.670
2ohj FMNType A flavoprotein FprA 1 0.669
3qe2 FMNNADPH--cytochrome P450 reductase / 0.668
4bca FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.665
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.665
3b03 VNRIsopentenyl-diphosphate delta-isomerase / 0.662
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.661
2c12 FADNitroalkane oxidase 1.7.3.1 0.660
4l82 FMNUncharacterized protein / 0.660
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.659
3rpe FADPutative modulator of drug activity / 0.659
3eo8 FMNPutative nitroreductase / 0.658
1z48 FMNNADPH dehydrogenase / 0.657
4rje FNRLactate oxidase / 0.657
2fcr FMNFlavodoxin / 0.656
3oix FMNDihydroorotate dehydrogenase / 0.655
2vxa RBFDodecin / 0.654
4eo3 FMNBacterioferritin comigratory protein/NADH dehydrogenase / 0.654
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.654
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.653
3gfd FMNIodotyrosine deiodinase 1 1.21.1.1 0.653
4cw5 FMNDfnA / 0.653
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.652
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.652
3fcj FADNitroalkane oxidase 1.7.3.1 0.652
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.651
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.651
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.650
3pfd FDAAcyl-CoA dehydrogenase FadE25 / 0.650
4iv6 FDAIsovaleryl-CoA dehydrogenase / 0.650