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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1bid UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1bid UMPThymidylate synthase / 0.993
1tsx UMPThymidylate synthase / 0.874
1tsy UMPThymidylate synthase / 0.868
1vzb UMPThymidylate synthase / 0.868
4e5o UMPThymidylate synthase 2.1.1.45 0.857
1f28 UMPThymidylate synthase 2.1.1.45 0.856
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.849
5by6 UMPThymidylate synthase / 0.849
2tdm UMPThymidylate synthase / 0.846
2vet UMPThymidylate synthase / 0.841
1bp6 UMPThymidylate synthase / 0.837
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.826
1tsv UMPThymidylate synthase / 0.826
1njc DCMThymidylate synthase / 0.823
4eb4 UMPThymidylate synthase 2.1.1.45 0.822
2g86 UMPThymidylate synthase / 0.820
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.815
2g8a UMPThymidylate synthase / 0.812
4ein NOHThymidylate synthase 2.1.1.45 0.811
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.810
4dq1 UMPThymidylate synthase / 0.797
1bp0 UMPThymidylate synthase / 0.792
2fto TMPThymidylate synthase / 0.791
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.786
4isk UMPThymidylate synthase / 0.785
1nja DCMThymidylate synthase / 0.783
3qj7 UMPThymidylate synthase ThyA / 0.772
4h0u UMPThymidylate synthase / 0.764
1bdu DURThymidylate synthase / 0.761
1jmh UMPThymidylate synthase / 0.761
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.754
3bgx TMPThymidylate synthase / 0.751
1tdu DURThymidylate synthase / 0.750
4psg NOHThymidylate synthase / 0.749
1jmf UMPThymidylate synthase / 0.748
1njd UMPThymidylate synthase / 0.741
1tys TMPThymidylate synthase / 0.738
2g89 UMPThymidylate synthase / 0.736
1ddu DDUThymidylate synthase / 0.731
1jmi UMPThymidylate synthase / 0.724
1bpj UMPThymidylate synthase / 0.720
1vza UMPThymidylate synthase / 0.716
4iqq UMPThymidylate synthase / 0.715
4irr UMPThymidylate synthase / 0.713
4fox UMPThymidylate synthase ThyA / 0.707
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.706
1jmg UMPThymidylate synthase / 0.706
1njb UMPThymidylate synthase / 0.701
1thy UMPThymidylate synthase / 0.697
2tsr UMPThymidylate synthase 2.1.1.45 0.691
1aob DDUThymidylate synthase / 0.685
2g8d UMPThymidylate synthase / 0.685
1nje DCMThymidylate synthase / 0.673
4p66 MTXDihydrofolate reductase / 0.651