Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1aq1 STU Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 1.080
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.896
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.895
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.867
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.863
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.846
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.834
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.828
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.822
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.821
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.809
3zew STUEphrin type-B receptor 4 2.7.10.1 0.807
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.797
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.792
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.791
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.775
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.773
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.768
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.767
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.764
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.763
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.756
1byg STUTyrosine-protein kinase CSK / 0.754
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.752
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.751
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.746
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.745
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.744
2in6 839Wee1-like protein kinase 2.7.10.2 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.737
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.737
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.719
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.714
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.714
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.708
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.701
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.700
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.699
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.688
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.686
3d7t STUTyrosine-protein kinase CSK / 0.680
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.679
4e4n 0NLTyrosine-protein kinase JAK1 / 0.678
2buj STUSerine/threonine-protein kinase 16 / 0.674
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.671
3ken ZZDKinesin-like protein KIF11 / 0.669
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.665
4f08 1RSTyrosine-protein kinase JAK2 / 0.664
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.656
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.655
2gni M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4c35 NU3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.651