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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1akb PPD Aspartate aminotransferase, mitochondrial 2.6.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 1.238
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 1.135
1ivr CBAAspartate aminotransferase, mitochondrial 2.6.1.1 1.076
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 1.070
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 1.023
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.991
1cq8 PY6Aspartate aminotransferase 2.6.1.1 0.969
1arh PPDAspartate aminotransferase 2.6.1.1 0.913
1cq7 PY5Aspartate aminotransferase 2.6.1.1 0.900
1x28 PGUAspartate aminotransferase 2.6.1.1 0.896
1cq6 PY4Aspartate aminotransferase 2.6.1.1 0.883
1arg PPDAspartate aminotransferase 2.6.1.1 0.872
1aka PLPAspartate aminotransferase, mitochondrial 2.6.1.1 0.867
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.830
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 0.817
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.782
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.762
4fl0 PLPAminotransferase ALD1, chloroplastic 2.6.1 0.762
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 0.759
4geb 0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.718
2gqn BLPCystathionine beta-lyase MetC 4.4.1.8 0.716
4emy PLPAminotransferase class I and II / 0.705
2bwp PLG5-aminolevulinate synthase 2.3.1.37 0.702
3ei8 PL5LL-diaminopimelate aminotransferase, chloroplastic / 0.698
4wxf PLGSerine hydroxymethyltransferase / 0.697
1dfo PLGSerine hydroxymethyltransferase 2.1.2.1 0.688
4je5 PLPAromatic/aminoadipate aminotransferase 1 2.6.1.39 0.688
3aej AA5Methionine gamma-lyase / 0.685
3ele PLPAminotransferase / 0.685
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.684
1ejb INJ6,7-dimethyl-8-ribityllumazine synthase 2.5.1.78 0.679
2ycn P61Tyrosine phenol-lyase 4.1.99.2 0.677
3vax PLPUncharacterized protein / 0.674
4rkd KETAminotransferase / 0.672
4ge7 0K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.668
4ge4 0KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.664
4gdy 0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.663
1toj HCIAspartate aminotransferase 2.6.1.1 0.662
4obu PLPPyridoxal-dependent decarboxylase domain protein / 0.662
4eb5 PLPCysteine desulfurase IscS 2 / 0.661
4wlj IK2Kynurenine--oxoglutarate transaminase 1 2.6.1.7 0.661
5k8b PDG8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase / 0.658
4wxg 2BOSerine hydroxymethyltransferase / 0.655
4d96 5PAD-cysteine desulfhydrase / 0.651