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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
6gsuGPSGlutathione S-transferase Mu 12.5.1.18

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
6gsuGPSGlutathione S-transferase Mu 12.5.1.181.000
1mtcGPRGlutathione S-transferase Mu 12.5.1.180.545
6gsvGPSGlutathione S-transferase Mu 12.5.1.180.544
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.474
2g8yNADHydroxycarboxylate dehydrogenase B/0.460
3gwfNAPCyclohexanone monooxygenase/0.454
1xe55FEPlasmepsin-23.4.23.390.453
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.453
2jn3JN3Fatty acid-binding protein, liver/0.453
3gnvXNZGenome polyprotein2.7.7.480.451
3i0pNADMalate dehydrogenase, putative/0.451
2v16C47Renin3.4.23.150.450
3h3qH13Collagen type IV alpha-3-binding protein/0.450
5fl3ADPPili retraction protein PilT/0.450
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.448
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.448
2dfvNADL-threonine 3-dehydrogenase/0.448
3ssmSAHMycinamicin VI 2''-O-methyltransferase/0.446
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.445
1h73ANPHomoserine kinase2.7.1.390.443
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.443
3ctyFADProbable thioredoxin reductase/0.443
3fvlBHKCarboxypeptidase A13.4.17.10.443
4b4vL34Bifunctional protein FolD/0.442
1r2jFADFkbI/0.441
2oapANPType II secretion system protein (GspE-2)/0.441