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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5jljGNPGTP-binding nuclear protein Ran

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5jljGNPGTP-binding nuclear protein Ran/1.000
5dhaGNPGTP-binding nuclear protein Ran/0.688
5difGNPGTP-binding nuclear protein Ran/0.606
3ea5GDPGTP-binding nuclear protein Ran/0.592
1ibrGNPGTP-binding nuclear protein Ran/0.574
1t91GTPRas-related protein Rab-7a/0.544
3a6pGTPGTP-binding nuclear protein Ran/0.544
1xtsGTPGTP-binding protein Rheb/0.541
3e5hGNPRas-related protein Rab-28/0.539
3rabGNPRas-related protein Rab-3A/0.538
1zbdGTPRas-related protein Rab-3A/0.535
3oesGNPGTPase RhebL1/0.535
4nyjGNPGTPase HRas/0.534
4rkfGNPRas-related protein Rab-3/0.533
3lbnGNPGTPase HRas/0.530
4dltGNPGTPase HRas/0.530
1yzqGNPRas-related protein Rab-6A/0.529
2bkuGTPGTP-binding nuclear protein Ran/0.529
3bc1GNPRas-related protein Rab-27A/0.529
4mitGTPRho-related protein racC/0.527
3oivGNPGTPase HRas/0.526
1g17GNPRas-related protein SEC4/0.524
1xtrGNPGTP-binding protein Rheb/0.524
3nbzGTPGTP-binding nuclear protein Ran/0.523
3rs5GNPGTPase HRas/0.523
3v4fGNPGTPase HRas/0.520
4qxaGTPRas-related protein Rab-9A/0.520
3tsoGNPRas-related protein Rab-25/0.519
4o25GTPGTP-binding protein Rheb/0.519
1vg8GNPRas-related protein Rab-7a/0.518
2fe4GDPRas-related protein Rab-6B/0.518
1k5dGNPGTP-binding nuclear protein Ran/0.517
3w3zGTPGTP-binding nuclear protein Ran/0.516
1yhnGTPRas-related protein Rab-7a/0.515
1kmqGNPTransforming protein RhoA/0.513
4lhwGNPRas-related protein Rab-8A/0.512
3bbpGTPRas-related protein Rab-6A/0.510
1cxzGSPTransforming protein RhoA/0.509
4nyiGNPGTPase HRas/0.499
5b2zGNPGTPase HRas/0.499
3rs7GNPGTPase HRas/0.498
2ffqGSPRas-related protein Rab-6B/0.497
3i3sGNPGTPase HRas/0.494
2zetGTPRas-related protein Rab-27B/0.493
1oixGDPRas-related protein Rab-11A/0.489
4dlwGNPGTPase HRas/0.487
1zc4GNPRas-related protein Ral-A/0.486
1e96GTPRas-related C3 botulinum toxin substrate 1/0.485
1s1cGNPTransforming protein RhoA/0.482
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.481
3eg5GNPCell division control protein 42 homolog/0.481
3kz1GSPTransforming protein RhoA/0.481
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.480
1z2cGNPRho-related GTP-binding protein RhoC/0.480
2clsGTPRho-related GTP-binding protein Rho6/0.479
3a58GNPGTP-binding protein RHO1/0.479
3oiuGNPGTPase HRas/0.479
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.479
4uj3GNPRas-related protein Rab-11A/0.477
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.476
3tklGTPRas-related protein Rab-1A/0.475
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.474
4xoiGTPTransforming protein RhoA/0.474
1zc3GNPRas-related protein Ral-A/0.471
3ddcGNPGTPase HRas/0.470
5hpyGDPTransforming protein RhoA/0.470
2c5lGTPGTPase HRas/0.468
3qbtGNPRas-related protein Rab-8A/0.468
1ow3GDPTransforming protein RhoA/0.467
3kkoGNPRas-related protein M-Ras/0.467
3th5GNPRas-related C3 botulinum toxin substrate 1/0.466
4g0nGNPGTPase HRas/0.465
2rgeGNPGTPase HRas/0.462
3kudGDPGTPase HRas/0.461
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.459
1m7bGTPRho-related GTP-binding protein RhoE/0.458
4dsnGCPGTPase KRas/0.458
3oiwGNPGTPase HRas/0.457
2gcpGSPRho-related GTP-binding protein RhoC/0.456
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.455
2rgbGNPGTPase HRas/0.455
3wyfGTPGTP-binding nuclear protein/0.455
3x1zGNPRas-related protein Rap-1b/0.455
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.453
4kvgGTPRas-related protein Rap-1A/0.453
3kucGDPRas-related protein Rap-1A/0.452
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.452
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.451
3rslGNPGTPase HRas/0.449
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.448
3lbhGNPGTPase HRas/0.446
4dxaGSPRas-related protein Rap-1b/0.444
3l8yGNPGTPase HRas/0.443
4dlxGNPGTPase HRas/0.443
4js0GNPCell division control protein 42 homolog/0.443
1zd9GDPADP-ribosylation factor-like protein 8A/0.442
4dlsGNPGTPase HRas/0.442
4l8gGDPGTPase KRas/0.442
4dlzGNPGTPase HRas/0.441
5c46GSPRas-related protein Rab-11A/0.440