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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iqaGNPBifunctional AAC/APH2.3.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5iqaGNPBifunctional AAC/APH2.3.11.000
5iqgGDPBifunctional AAC/APH2.3.10.677
5bylGCPBifunctional AAC/APH2.3.10.656
5iqhGNPBifunctional AAC/APH2.3.10.648
5iqbGNPBifunctional AAC/APH2.3.10.639
5iqdGNPBifunctional AAC/APH2.3.10.637
5iqiGNPBifunctional AAC/APH2.3.10.601
5iqeGNPBifunctional AAC/APH2.3.10.595
4orkGDPBifunctional AAC/APH2.3.10.540
2puiADPMethylthioribose kinase2.7.1.1000.467
4ix5ANPUncharacterized protein/0.459
1h83FADPolyamine oxidase1.5.3.140.458
3wowANPCasein kinase II subunit alpha2.7.11.10.454
2r0cFADPutative FAD-monooxygenase/0.452
2hq9FADMll6688 protein/0.447
3kpfFADPolyamine oxidase1.5.3.140.447
2pupADPMethylthioribose kinase2.7.1.1000.443
1x8b824Wee1-like protein kinase2.7.10.20.442
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.440