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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hi6MTXDihydrofolate reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5hi6MTXDihydrofolate reductase/1.000
4dfrMTXDihydrofolate reductase1.5.1.30.570
1ddsMTXDihydrofolate reductase1.5.1.30.562
1draMTXDihydrofolate reductase1.5.1.30.561
1rb3MTXDihydrofolate reductase1.5.1.30.551
1re7FOLDihydrofolate reductase1.5.1.30.549
1ddrMTXDihydrofolate reductase1.5.1.30.546
1jolFFODihydrofolate reductase1.5.1.30.545
2drcMTXDihydrofolate reductase1.5.1.30.545
1dyjDDFDihydrofolate reductase1.5.1.30.542
1dhjMTXDihydrofolate reductase1.5.1.30.539
3och2MXDihydrofolate reductase1.5.1.30.514
1drbMTXDihydrofolate reductase1.5.1.30.508
1tdrMTXDihydrofolate reductase1.5.1.30.508
3drcMTXDihydrofolate reductase1.5.1.30.505
1dyiFOLDihydrofolate reductase1.5.1.30.499
4cd2FOLDihydrofolate reductase1.5.1.30.496
1rd7FOLDihydrofolate reductase1.5.1.30.494
1rb2FOLDihydrofolate reductase1.5.1.30.483
4x5iFOLDihydrofolate reductase1.5.1.30.481
1dyhDZFDihydrofolate reductase1.5.1.30.479
4x5jFOLDihydrofolate reductase1.5.1.30.479
1rf7DHFDihydrofolate reductase1.5.1.30.469
4qi9MTXDihydrofolate reductase/0.466
1ra8FOLDihydrofolate reductase1.5.1.30.453
2cig1DGDihydrofolate reductase1.5.1.30.451
2d0kFOLDihydrofolate reductase1.5.1.30.451
1diuBDMDihydrofolate reductase1.5.1.30.448
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3qlrNDPDihydrofolate reductase1.5.1.30.444