sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5dw0 | PLS | Tryptophan synthase beta chain 1 | 4.2.1.20 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5dw0 | PLS | Tryptophan synthase beta chain 1 | 4.2.1.20 | 1.000 | |
| 2tys | PLT | Tryptophan synthase beta chain | 4.2.1.20 | 0.506 | |
| 2trs | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.477 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.458 | |
| 1e2j | THM | Thymidine kinase | / | 0.450 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.450 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.450 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.448 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.447 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.445 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.445 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.443 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 |