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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.11.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.477
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.452
4jia1K3Tyrosine-protein kinase JAK2/0.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
3nux3NVCyclin-dependent kinase 62.7.11.220.442
4bcmT7ZCyclin-dependent kinase 22.7.11.220.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.440