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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xvqGNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4xvqGNPGTPase HRas/1.000
2rggGNPGTPase HRas/0.669
3tgpGNPGTPase HRas/0.654
4xvrGNPGTPase HRas/0.626
4hdqGNPRas-related protein Rap-1b/0.625
1uadGNPRas-related protein Ral-A/0.586
3kkoGNPRas-related protein M-Ras/0.564
4lpkGDPGTPase KRas/0.545
2rgeGNPGTPase HRas/0.540
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.524
4epwGDPGTPase KRas/0.524
4l8gGDPGTPase KRas/0.518
1zc4GNPRas-related protein Ral-A/0.515
2fe4GDPRas-related protein Rab-6B/0.515
4l9sGDPGTPase HRas/0.514
3kkqGDPRas-related protein M-Ras/0.512
2rgcGNPGTPase HRas/0.506
2ce2GDPGTPase HRas/0.499
4wa7GDPGTPase KRas/0.499
3ddcGNPGTPase HRas/0.498
3k9lGNPGTPase HRas/0.498
3k8yGNPGTPase HRas/0.497
4tq9GDPGTPase KRas/0.493
2cl6CAGGTPase HRas/0.491
1z2aGDPRas-related protein Rab-23/0.488
4lucGDPGTPase KRas/0.488
3oivGNPGTPase HRas/0.486
3lbhGNPGTPase HRas/0.482
3mjhGTPRas-related protein Rab-5A/0.479
3v4fGNPGTPase HRas/0.478
3oesGNPGTPase RhebL1/0.475
3pitGNPRas-related protein M-Ras/0.475
4obeGDPGTPase KRas/0.475
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.474
2fg5GNPRas-related protein Rab-31/0.473
3cphGDPRas-related protein SEC4/0.469
2c5lGTPGTPase HRas/0.468
4lrwGDPGTPase KRas/0.468
4q02GDPGTPase KRas/0.467
1lfdGNPGTPase HRas/0.466
2q3fGNPRas-related GTP-binding protein D/0.466
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.465
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.465
4q03GDPGTPase KRas/0.465
4ql3GDPGTPase KRas/0.465
3i3sGNPGTPase HRas/0.460
4epxGDPGTPase KRas/0.459
1e96GTPRas-related C3 botulinum toxin substrate 1/0.457
4kq2U5PGlycogen [starch] synthase isoform 22.4.1.110.457
4nyjGNPGTPase HRas/0.457
1n6lGTPRas-related protein Rab-5A/0.456
4lv6GDPGTPase KRas/0.456
4ldjGDPGTPase KRas/0.455
3vhxGTPADP-ribosylation factor 6/0.454
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.453
3qbtGNPRas-related protein Rab-8A/0.453
3s3vTOPDihydrofolate reductase1.5.1.30.453
1oixGDPRas-related protein Rab-11A/0.451
1xtsGTPGTP-binding protein Rheb/0.450
2rgbGNPGTPase HRas/0.450
4dltGNPGTPase HRas/0.450
4q71FADBifunctional protein PutA/0.450
1yu9GNPRas-related protein Rab-4A/0.449
3oafOAGDihydrofolate reductase1.5.1.30.449
3x1zGNPRas-related protein Rap-1b/0.449
3lbnGNPGTPase HRas/0.448
4dsnGCPGTPase KRas/0.447
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.446
4o2rGDPGTP-binding protein Rheb/0.446
1xtrGNPGTP-binding protein Rheb/0.445
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.445
3oiuGNPGTPase HRas/0.445
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.444
2mscGDPMHC class I alpha chain/0.444
3qlrNDPDihydrofolate reductase1.5.1.30.444
1mvsDTMDihydrofolate reductase1.5.1.30.443
3rs5GNPGTPase HRas/0.443
4q72FADBifunctional protein PutA/0.442
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.441
1x1rGDPRas-related protein M-Ras/0.440
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.440
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.440
3kz1GSPTransforming protein RhoA/0.440
4uj3GNPRas-related protein Rab-11A/0.440