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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.11.000
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.508
3p79P79Mitogen-activated protein kinase 14/0.489
2puuG2GMitogen-activated protein kinase 14/0.478
3gcuR48Mitogen-activated protein kinase 14/0.478
1kv1BMUMitogen-activated protein kinase 14/0.477
3nnuEDBMitogen-activated protein kinase 14/0.476
3p5kP5KMitogen-activated protein kinase 14/0.474
3gi3B10Mitogen-activated protein kinase 14/0.472
3hv71AUMitogen-activated protein kinase 14/0.472
3ugc046Tyrosine-protein kinase JAK2/0.471
3e9319BMitogen-activated protein kinase 14/0.466
2hz0GINTyrosine-protein kinase ABL12.7.10.20.463
4r7iSTIMacrophage colony-stimulating factor 1 receptor2.7.10.10.462
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.459
3k3jF4CMitogen-activated protein kinase 14/0.458
3npcB96Mitogen-activated protein kinase 92.7.11.240.458
3o8uBMUMitogen-activated protein kinase 14/0.451
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.450
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.448
3sp9IL2Peroxisome proliferator-activated receptor delta/0.446
2btrU73Cyclin-dependent kinase 22.7.11.220.445
2uxuNARHTH-type transcriptional regulator TtgR/0.445
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.445
1wbvLI3Mitogen-activated protein kinase 14/0.444
3hv4L51Mitogen-activated protein kinase 14/0.444
3p7bP7BMitogen-activated protein kinase 14/0.444
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.444
4hw764MMacrophage colony-stimulating factor 1 receptor2.7.10.10.444
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
3ogqAB1Pol polyprotein/0.443
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.443
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.441
2a7r5GPGMP reductase 2/0.440