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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tq9GDPGTPase KRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4tq9GDPGTPase KRas/1.000
4l9sGDPGTPase HRas/0.612
3kkqGDPRas-related protein M-Ras/0.588
4lv6GDPGTPase KRas/0.588
4epwGDPGTPase KRas/0.587
4ql3GDPGTPase KRas/0.586
4q03GDPGTPase KRas/0.585
2fe4GDPRas-related protein Rab-6B/0.584
4epxGDPGTPase KRas/0.584
4obeGDPGTPase KRas/0.578
4xvrGNPGTPase HRas/0.578
4lpkGDPGTPase KRas/0.576
2rggGNPGTPase HRas/0.555
3ddcGNPGTPase HRas/0.555
4l8gGDPGTPase KRas/0.555
4q02GDPGTPase KRas/0.553
4wa7GDPGTPase KRas/0.550
4hdqGNPRas-related protein Rap-1b/0.549
3kkoGNPRas-related protein M-Ras/0.548
4ldjGDPGTPase KRas/0.546
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.541
2fg5GNPRas-related protein Rab-31/0.540
2ce2GDPGTPase HRas/0.539
3tgpGNPGTPase HRas/0.539
1x1rGDPRas-related protein M-Ras/0.538
4o2rGDPGTP-binding protein Rheb/0.538
3lbhGNPGTPase HRas/0.536
3l8yGNPGTPase HRas/0.535
3x1zGNPRas-related protein Rap-1b/0.535
1lfdGNPGTPase HRas/0.534
1n6lGTPRas-related protein Rab-5A/0.533
4nyiGNPGTPase HRas/0.529
3v4fGNPGTPase HRas/0.526
4xvqGNPGTPase HRas/0.525
4lrwGDPGTPase KRas/0.523
1uadGNPRas-related protein Ral-A/0.522
3k9lGNPGTPase HRas/0.520
3tsoGNPRas-related protein Rab-25/0.519
3cphGDPRas-related protein SEC4/0.517
4dsnGCPGTPase KRas/0.517
3pitGNPRas-related protein M-Ras/0.516
3i3sGNPGTPase HRas/0.515
4nyjGNPGTPase HRas/0.514
1xtsGTPGTP-binding protein Rheb/0.512
3x1wGDPRas-related protein Rap-1b/0.512
2c5lGTPGTPase HRas/0.511
4dltGNPGTPase HRas/0.510
2rgcGNPGTPase HRas/0.509
4g0nGNPGTPase HRas/0.509
2rgeGNPGTPase HRas/0.508
3lbiGNPGTPase HRas/0.507
3oivGNPGTPase HRas/0.507
3rs4GNPGTPase HRas/0.507
5b2zGNPGTPase HRas/0.507
2rgbGNPGTPase HRas/0.506
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.504
3rs0GNPGTPase HRas/0.504
3lbnGNPGTPase HRas/0.502
2cl6CAGGTPase HRas/0.501
4dsuGDPGTPase KRas/0.500
1zd9GDPADP-ribosylation factor-like protein 8A/0.499
3oiuGNPGTPase HRas/0.498
2bmeGNPRas-related protein Rab-4A/0.497
1yu9GNPRas-related protein Rab-4A/0.496
4qxaGTPRas-related protein Rab-9A/0.495
4dxaGSPRas-related protein Rap-1b/0.494
4mitGTPRho-related protein racC/0.494
3kucGDPRas-related protein Rap-1A/0.492
1zc4GNPRas-related protein Ral-A/0.491
2mscGDPMHC class I alpha chain/0.490
3k8yGNPGTPase HRas/0.490
3oiwGNPGTPase HRas/0.490
4dlzGNPGTPase HRas/0.488
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.487
4dlsGNPGTPase HRas/0.484
4lhwGNPRas-related protein Rab-8A/0.484
4uj3GNPRas-related protein Rab-11A/0.483
3vhxGTPADP-ribosylation factor 6/0.482
5dhaGNPGTP-binding nuclear protein Ran/0.481
3kudGDPGTPase HRas/0.480
3rslGNPGTPase HRas/0.479
4hdoGNPRas-related protein Rap-1b/0.479
5c46GSPRas-related protein Rab-11A/0.479
1yzqGNPRas-related protein Rab-6A/0.477
3e5hGNPRas-related protein Rab-28/0.477
3oesGNPGTPase RhebL1/0.477
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.474
3rs5GNPGTPase HRas/0.473
4rkfGNPRas-related protein Rab-3/0.473
4dlvGNPGTPase HRas/0.470
5difGNPGTP-binding nuclear protein Ran/0.470
1zbdGTPRas-related protein Rab-3A/0.469
4o25GTPGTP-binding protein Rheb/0.469
4o2lGTPGTP-binding protein Rheb/0.469
1a2bGSPTransforming protein RhoA/0.468
3w3zGTPGTP-binding nuclear protein Ran/0.468
4dlxGNPGTPase HRas/0.468
1g17GNPRas-related protein SEC4/0.467
1tu3GNPRas-related protein Rab-5A/0.467
1z2aGDPRas-related protein Rab-23/0.466
3rs7GNPGTPase HRas/0.466
4dlwGNPGTPase HRas/0.465
1g16GDPRas-related protein SEC4/0.463
4uj5GNPRas-related protein Rab-11A/0.462
3a6pGTPGTP-binding nuclear protein Ran/0.461
5jljGNPGTP-binding nuclear protein Ran/0.461
3pcrGTPADP-ribosylation factor 6/0.459
1oixGDPRas-related protein Rab-11A/0.456
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.456
4dsoGSPGTPase KRas/0.456
4kvgGTPRas-related protein Rap-1A/0.456
1e96GTPRas-related C3 botulinum toxin substrate 1/0.454
1t91GTPRas-related protein Rab-7a/0.454
2q3fGNPRas-related GTP-binding protein D/0.453
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.452
1ibrGNPGTP-binding nuclear protein Ran/0.450
1xzqFONtRNA modification GTPase MnmE3.6.50.450
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.450
4l9wGNPGTPase HRas/0.450
5iqiGNPBifunctional AAC/APH2.3.10.449
1d5cGDPGTPase (Rab6)/0.448
1ky2GNPGTP-binding protein YPT7/0.448
3eg5GNPCell division control protein 42 homolog/0.448
3p67FMNPentaerythritol tetranitrate reductase/0.447
3bbpGTPRas-related protein Rab-6A/0.446
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.446
5hpyGDPTransforming protein RhoA/0.446
1v8kANPKinesin-like protein KIF2C/0.445
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.445
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.444
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.444
1s1cGNPTransforming protein RhoA/0.443
3p74FMNPentaerythritol tetranitrate reductase/0.443
1hb1OCVIsopenicillin N synthase1.21.3.10.442
3a58GNPGTP-binding protein RHO1/0.442
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.442