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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tjy3GNTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4tjy3GNTankyrase-22.4.2.301.000
4pnmNU1Tankyrase-22.4.2.300.615
4bj9UHBTankyrase-22.4.2.300.542
4k4eK4ETankyrase-12.4.2.300.539
4mt92D6Tankyrase-12.4.2.300.527
4li81XQTankyrase-12.4.2.300.522
4tkg09LTankyrase-22.4.2.300.519
4bjbP34Tankyrase-22.4.2.300.517
4pnrG18Tankyrase-22.4.2.300.513
4hyf1AKTankyrase-22.4.2.300.508
4bjcRPBTankyrase-22.4.2.300.506
4li71XPTankyrase-12.4.2.300.499
4i9i1DYTankyrase-12.4.2.300.488
4li61XOTankyrase-12.4.2.300.487
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.485
4krs1SXTankyrase-12.4.2.300.477
4n4v2GYTankyrase-12.4.2.300.466
2zitNADExotoxin A2.4.2.360.460
3u9y09LTankyrase-22.4.2.300.457
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.454
1xk9P34Exotoxin A2.4.2.360.453
3b82NADExotoxin A2.4.2.360.453
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.447
4msk2C8Tankyrase-12.4.2.300.445
3b78NADExotoxin A2.4.2.360.443