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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.528
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.524
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.514
2xvdAS6Ephrin type-B receptor 42.7.10.10.492
3w2sW2REpidermal growth factor receptor2.7.10.10.491
4gk4L90Ephrin type-A receptor 32.7.10.10.478
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.477
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.475
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.472
4jia1K3Tyrosine-protein kinase JAK2/0.472
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.471
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.468
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.467
4id71G0Activated CDC42 kinase 1/0.464
2c6eHPMAurora kinase A2.7.11.10.463
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.461
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.455
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.453
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.452
4eym0RXMitogen-activated protein kinase 132.7.11.240.452
2fgiPD1Fibroblast growth factor receptor 1/0.450
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.447
2qocANPEphrin type-A receptor 32.7.10.10.447
3vs1VSATyrosine-protein kinase HCK2.7.10.20.447
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2x9fX9FEphrin type-B receptor 42.7.10.10.445
3vs3VSETyrosine-protein kinase HCK2.7.10.20.443
2j7t274Serine/threonine-protein kinase 102.7.11.10.441
4ansVGHALK tyrosine kinase receptor2.7.10.10.441
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.440