Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.528
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.524
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.514
2xvdAS6Ephrin type-B receptor 42.7.10.10.492
3w2sW2REpidermal growth factor receptor2.7.10.10.491
4gk4L90Ephrin type-A receptor 32.7.10.10.478
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.477
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.475
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.472
4jia1K3Tyrosine-protein kinase JAK2/0.472
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.471
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.468
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.467
4id71G0Activated CDC42 kinase 1/0.464
2c6eHPMAurora kinase A2.7.11.10.463
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.461
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.455
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.453
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.452
4eym0RXMitogen-activated protein kinase 132.7.11.240.452
2fgiPD1Fibroblast growth factor receptor 1/0.450
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.447
2qocANPEphrin type-A receptor 32.7.10.10.447
3vs1VSATyrosine-protein kinase HCK2.7.10.20.447
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2x9fX9FEphrin type-B receptor 42.7.10.10.445
3vs3VSETyrosine-protein kinase HCK2.7.10.20.443
2j7t274Serine/threonine-protein kinase 102.7.11.10.441
4ansVGHALK tyrosine kinase receptor2.7.10.10.441
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.440