sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4mmc	29J	Na(+):neurotransmitter symporter (Snf family)

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4mmc	29J	Na(+):neurotransmitter symporter (Snf family)	/	1.000
4mm9	FVX	Na(+):neurotransmitter symporter (Snf family)	/	0.604
4mm7	29J	Na(+):neurotransmitter symporter (Snf family)	/	0.584
4mme	29Q	Na(+):neurotransmitter symporter (Snf family)	/	0.566
4mmf	29Q	Na(+):neurotransmitter symporter (Snf family)	/	0.566
4mm4	8PR	Na(+):neurotransmitter symporter (Snf family)	/	0.547
4mmd	29E	Na(+):neurotransmitter symporter (Snf family)	/	0.537
4xp1	LDP	Sodium-dependent dopamine transporter	/	0.455