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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.101.000
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.614
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.604
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.561
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.547
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.524
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.517
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.499
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.494
3iczPB6Farnesyl pyrophosphate synthase/0.486
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.471
1zdwFLVPrenyltransferase/0.470
4ph9IBPProstaglandin G/H synthase 21.14.99.10.461
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.460
3mqe416Prostaglandin G/H synthase 21.14.99.10.459
3wsbRWZFarnesyltransferase, putative/0.450
3pghFLPProstaglandin G/H synthase 21.14.99.10.449
3rywK9HFarnesyl pyrophosphate synthase, putative/0.449
3q7dNPXProstaglandin G/H synthase 21.14.99.10.446
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.446
5emhNAPIridoid synthase1.3.1.990.445
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.444
2bx8AZQSerum albumin/0.441