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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.571
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.461
1gerFADGlutathione reductase1.8.1.70.453
1febFADTrypanothione reductase1.8.1.120.447
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.447
1grhFADGlutathione reductase, mitochondrial1.8.1.70.443
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.443