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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kn2LYAFolate receptor beta

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kn2LYAFolate receptor beta/1.000
4kn0MTXFolate receptor beta/0.620
4lrhFOLFolate receptor alpha/0.614
4kn104JFolate receptor beta/0.592
4kmzFOLFolate receptor beta/0.571
4fam0SZAldo-keto reductase family 1 member C3/0.474
1s1rNAPAldo-keto reductase family 1 member C3/0.466
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.462
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.462
1ry8RUTAldo-keto reductase family 1 member C3/0.461
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.454
4dbw511Aldo-keto reductase family 1 member C3/0.448
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
1q83TZ5Acetylcholinesterase3.1.1.70.445
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.444
4nv10FXFormyl transferase/0.444
1ry0PG2Aldo-keto reductase family 1 member C3/0.443
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.441
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.441
4b7zQ4QAcetylcholinesterase3.1.1.70.441
2xufTZ4Acetylcholinesterase3.1.1.70.440