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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kiq1RAMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kiq1RAMitogen-activated protein kinase 14/1.000
4aacAAVMitogen-activated protein kinase 14/0.609
4aa5NQBMitogen-activated protein kinase 14/0.607
3fklFKLMitogen-activated protein kinase 14/0.590
4aa4QC0Mitogen-activated protein kinase 14/0.578
3fln3FNMitogen-activated protein kinase 14/0.567
3hl7I47Mitogen-activated protein kinase 14/0.566
3mvl38PMitogen-activated protein kinase 14/0.561
3iphG11Mitogen-activated protein kinase 14/0.555
4kip1R9Mitogen-activated protein kinase 14/0.552
3nww3NWMitogen-activated protein kinase 14/0.551
2balPQAMitogen-activated protein kinase 14/0.546
3s4qNK0Mitogen-activated protein kinase 14/0.542
3ocgOCGMitogen-activated protein kinase 14/0.530
4lopSB4Mitogen-activated protein kinase 14/0.529
3mpt1GKMitogen-activated protein kinase 14/0.528
3flwFLWMitogen-activated protein kinase 14/0.523
3fmh533Mitogen-activated protein kinase 14/0.519
2rg5279Mitogen-activated protein kinase 14/0.514
4kin1M8Mitogen-activated protein kinase 14/0.509
3dt1P40Mitogen-activated protein kinase 14/0.508
3fi4FI4Mitogen-activated protein kinase 14/0.507
3fmkFMKMitogen-activated protein kinase 14/0.507
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.506
2rg6287Mitogen-activated protein kinase 14/0.502
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.498
1zyjBI5Mitogen-activated protein kinase 14/0.496
3flyFLYMitogen-activated protein kinase 14/0.495
3flzFLZMitogen-activated protein kinase 14/0.495
3hllI45Mitogen-activated protein kinase 14/0.493
3fskRO6Mitogen-activated protein kinase 14/0.492
4looSB4Mitogen-activated protein kinase 14/0.492
4loqSB4Mitogen-activated protein kinase 14/0.486
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.485
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.484
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.483
3l8xN4DMitogen-activated protein kinase 14/0.482
3w33W19Epidermal growth factor receptor2.7.10.10.482
4y93746Tyrosine-protein kinase/0.481
1zz2B11Mitogen-activated protein kinase 14/0.480
3uvqFS8Mitogen-activated protein kinase 14/0.479
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.478
3hvcGG5Mitogen-activated protein kinase 14/0.478
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.474
3uyt0CKCasein kinase I isoform delta2.7.11.10.473
1ywrLI9Mitogen-activated protein kinase 14/0.471
4ic7ANPMitogen-activated protein kinase 72.7.11.240.471
1phePIYCamphor 5-monooxygenase1.14.15.10.470
3gubGUBDeath-associated protein kinase 12.7.11.10.469
3u8w09JMitogen-activated protein kinase 14/0.469
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.469
4y95746Tyrosine-protein kinase/0.469
1py5PY1TGF-beta receptor type-12.7.11.300.467
3vryB43Tyrosine-protein kinase HCK2.7.10.20.467
1dz6CAMCamphor 5-monooxygenase1.14.15.10.466
2y6o1N1Ephrin type-A receptor 42.7.10.10.466
3mvm39PMitogen-activated protein kinase 14/0.466
3roc29AMitogen-activated protein kinase 14/0.465
2ghlLIBMitogen-activated protein kinase 14/0.464
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.464
4dpwAGSMevalonate diphosphate decarboxylase/0.463
4i22IREEpidermal growth factor receptor2.7.10.10.463
1t85CAMCamphor 5-monooxygenase1.14.15.10.462
1xkkFMMEpidermal growth factor receptor2.7.10.10.462
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.462
3vjoANPEpidermal growth factor receptor2.7.10.10.461
3fwiCAMCamphor 5-monooxygenase1.14.15.10.460
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.460
1dz4CAMCamphor 5-monooxygenase1.14.15.10.459
1v0pPVBCell division control protein 2 homolog2.7.11.220.459
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
4fob0USALK tyrosine kinase receptor2.7.10.10.459
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.458
4g170VNCasein kinase I isoform gamma-32.7.11.10.458
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
1o76CAMCamphor 5-monooxygenase1.14.15.10.457
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
2a1nCAMCamphor 5-monooxygenase1.14.15.10.456
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.456
4riyADPEpidermal growth factor receptor2.7.10.10.456
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.455
2qd9LGFMitogen-activated protein kinase 14/0.455
4ek1CAMCamphor 5-monooxygenase1.14.15.10.455
2itnANPEpidermal growth factor receptor2.7.10.10.454
2qboCAMCamphor 5-monooxygenase1.14.15.10.454
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.454
1t86CAMCamphor 5-monooxygenase1.14.15.10.453
2cppCAMCamphor 5-monooxygenase1.14.15.10.453
3gfeP37Mitogen-activated protein kinase 14/0.453
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.452
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.452
2ittAEEEpidermal growth factor receptor2.7.10.10.451
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.451
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.450
3uvp048Mitogen-activated protein kinase 14/0.450
3zuyTCHTransporter/0.450
2itpAEEEpidermal growth factor receptor2.7.10.10.449
2wouZZFTGF-beta receptor type-12.7.11.300.449
4b99R4LMitogen-activated protein kinase 72.7.11.240.449
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.449
1phgMYTCamphor 5-monooxygenase1.14.15.10.448
1uyuCAMCamphor 5-monooxygenase1.14.15.10.448
2qblCAMCamphor 5-monooxygenase1.14.15.10.448
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.448
4l4cCAMCamphor 5-monooxygenase1.14.15.10.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
6cp4CAMCamphor 5-monooxygenase1.14.15.10.448
3qakUKAAdenosine receptor A2a/0.448
2a1oCAMCamphor 5-monooxygenase1.14.15.10.447
4cp4CAMCamphor 5-monooxygenase1.14.15.10.447
4c02TAKActivin receptor type-12.7.11.300.446
4l4dCAMCamphor 5-monooxygenase1.14.15.10.446
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.445
3gc9B45Mitogen-activated protein kinase 112.7.11.240.445
1tehNADAlcohol dehydrogenase class-31.1.1.10.444
2a1mCAMCamphor 5-monooxygenase1.14.15.10.444
2qo9ANPEphrin type-A receptor 32.7.10.10.444
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.444
4jq8KJ8Epidermal growth factor receptor2.7.10.10.444
4kb81QOCasein kinase I isoform delta2.7.11.10.444
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.444
1iwjCAMCamphor 5-monooxygenase1.14.15.10.443
2wotZZGTGF-beta receptor type-12.7.11.300.443
3ac2KSETyrosine-protein kinase Lck2.7.10.20.443
4gk2L66Ephrin type-A receptor 32.7.10.10.443
4gk3L87Ephrin type-A receptor 32.7.10.10.443
4hjoAQ4Epidermal growth factor receptor2.7.10.10.443
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.442
1t88CAMCamphor 5-monooxygenase1.14.15.10.442
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3ukuC69Actin-related protein 3/0.442
4fv9E71Mitogen-activated protein kinase 12.7.11.240.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
4icyFADPgaE/0.442
2yyuC5POrotidine 5'-phosphate decarboxylase/0.441
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.441
4hnf16WCasein kinase I isoform delta2.7.11.10.441
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.440
2qbmCAMCamphor 5-monooxygenase1.14.15.10.440
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.440
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.440
4i231C9Epidermal growth factor receptor2.7.10.10.440
4j54G52Gag-Pol polyprotein3.4.23.160.440
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.440