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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kfj1R0Dihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kfj1R0Dihydrofolate reductase1.5.1.31.000
4kd79DRDihydrofolate reductase1.5.1.30.579
4kak06UDihydrofolate reductase1.5.1.30.572
3k47D09Dihydrofolate reductase1.5.1.30.549
3nxoD2BDihydrofolate reductase1.5.1.30.527
3nxtD2EDihydrofolate reductase1.5.1.30.527
3nxyD2HDihydrofolate reductase1.5.1.30.518
3nxrD2DDihydrofolate reductase1.5.1.30.515
3nxvD2FDihydrofolate reductase1.5.1.30.512
2w3aTOPDihydrofolate reductase1.5.1.30.507
1bozPRDDihydrofolate reductase1.5.1.30.493
1s3wTQTDihydrofolate reductase1.5.1.30.491
4ddrMMVDihydrofolate reductase1.5.1.30.489
3cseN22Uncharacterized protein/0.485
1hfqMOTDihydrofolate reductase1.5.1.30.484
1hfrMOTDihydrofolate reductase1.5.1.30.467
1dlrMXADihydrofolate reductase1.5.1.30.464
3qlxQLRUncharacterized protein/0.460
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.455
1dr4HBIDihydrofolate reductase1.5.1.30.453
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
1dr2TAPDihydrofolate reductase1.5.1.30.449
1dr5NAPDihydrofolate reductase1.5.1.30.449
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.449
3eek53SUncharacterized protein/0.447
1cd2FOLDihydrofolate reductase1.5.1.30.445
1hfpMOTDihydrofolate reductase1.5.1.30.445
3eem53VUncharacterized protein/0.445
4qjcIXEDihydrofolate reductase1.5.1.30.440