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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j22AJ7Tankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4j22AJ7Tankyrase-22.4.2.301.000
4bud29FTankyrase-22.4.2.300.714
4bufF36Tankyrase-22.4.2.300.613
4kzuA73Tankyrase-22.4.2.300.611
4l31F08Tankyrase-22.4.2.300.602
4hlk431Tankyrase-22.4.2.300.598
4hknLU2Tankyrase-22.4.2.300.591
4l10A63Tankyrase-22.4.2.300.589
3kr8XAVTankyrase-22.4.2.300.587
4buuF38Tankyrase-22.4.2.300.579
4l0s1UZTankyrase-22.4.2.300.570
4bu908CTankyrase-22.4.2.300.566
4but31FTankyrase-22.4.2.300.559
4buiW2ETankyrase-22.4.2.300.556
4hkkAGITankyrase-22.4.2.300.555
4l0t1V0Tankyrase-22.4.2.300.539
4hlg20BTankyrase-22.4.2.300.487
4l341VGTankyrase-22.4.2.300.480
4msk2C8Tankyrase-12.4.2.300.463
4iueAJ4Tankyrase-22.4.2.300.462
4tkg09LTankyrase-22.4.2.300.446