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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hlk431Tankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hlk431Tankyrase-22.4.2.301.000
4buuF38Tankyrase-22.4.2.300.720
4buiW2ETankyrase-22.4.2.300.707
4but31FTankyrase-22.4.2.300.698
4l0s1UZTankyrase-22.4.2.300.686
4bu908CTankyrase-22.4.2.300.666
4bufF36Tankyrase-22.4.2.300.628
3kr8XAVTankyrase-22.4.2.300.583
4l31F08Tankyrase-22.4.2.300.582
4bud29FTankyrase-22.4.2.300.580
4kzuA73Tankyrase-22.4.2.300.566
4j22AJ7Tankyrase-22.4.2.300.558
4hknLU2Tankyrase-22.4.2.300.542
4hkkAGITankyrase-22.4.2.300.537
4l10A63Tankyrase-22.4.2.300.530
4l0t1V0Tankyrase-22.4.2.300.455
4l341VGTankyrase-22.4.2.300.451