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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h3qANPMitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4h3qANPMitogen-activated protein kinase 12.7.11.241.000
4nifANPMitogen-activated protein kinase 12.7.11.240.534
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.481
4fmqANPMitogen-activated protein kinase 12.7.11.240.462
2y9qANPMitogen-activated protein kinase 12.7.11.240.461
4fv9E71Mitogen-activated protein kinase 12.7.11.240.456
4fv6E57Mitogen-activated protein kinase 12.7.11.240.454