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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.301.000
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.727
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.601
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.513
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.487
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.474
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.456
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.452
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.443