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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gevCB3Thymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4gevCB3Thymidylate synthase/1.000
2ftoCB3Thymidylate synthase/0.600
4knzCB3Thymidylate synthase/0.591
3bgxMEFThymidylate synthase/0.559
1tysDHFThymidylate synthase/0.526
4isk1JYThymidylate synthase/0.523
1tduCB3Thymidylate synthase/0.513
3bhlTHGThymidylate synthase/0.505
1fwmCB3Thymidylate synthase/0.503
3bhrTHGThymidylate synthase/0.501
1f4fTP3Thymidylate synthase/0.494
1dduCB3Thymidylate synthase/0.486
4fogC2FThymidylate synthase ThyA/0.481
4ez8DHFThymidylate synthase2.1.1.450.477
4o7uTHFThymidylate synthase/0.465
1an5CB3Thymidylate synthase/0.462
1f4gTP4Thymidylate synthase/0.457
3bgxTMPThymidylate synthase/0.450
2ftoTMPThymidylate synthase/0.448
4fqsLYAThymidylate synthase ThyA/0.443