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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fxy0W2Neurolysin, mitochondrial3.4.24.16

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fxy0W2Neurolysin, mitochondrial3.4.24.161.000
2ejvNADL-threonine 3-dehydrogenase/0.460
3qt62P0Mevalonate diphosphate decarboxylase/0.456
1p9wANPType II secretion system protein E/0.453
1w6hTITPlasmepsin-23.4.23.390.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
2dvlFADAcyl-CoA dehydrogenase/0.450
4bfzZVZPantothenate kinase2.7.1.330.449
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1t2cNAIL-lactate dehydrogenase1.1.1.270.448
1omoNADAlanine dehydrogenase/0.446
4tyqAP5Adenylate kinase/0.446
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
1xelUPGUDP-glucose 4-epimerase5.1.3.20.444
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.442
3hazFADBifunctional protein PutA/0.442
1h50FMNPentaerythritol tetranitrate reductase/0.441
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
4dptAGSMevalonate diphosphate decarboxylase/0.441
2ab8MTPAdenosine kinase2.7.1.200.440
4zj8SUVOrexin receptor type 1/0.440