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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fogC2FThymidylate synthase ThyA

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fogC2FThymidylate synthase ThyA/1.000
3bgxMEFThymidylate synthase/0.553
3bhrTHGThymidylate synthase/0.535
3bgxTMPThymidylate synthase/0.511
1tysDHFThymidylate synthase/0.508
3bhlTHGThymidylate synthase/0.478
1tysTMPThymidylate synthase/0.456
1an5CB3Thymidylate synthase/0.453
4knzCB3Thymidylate synthase/0.453
2ftoCB3Thymidylate synthase/0.451
4isk1JYThymidylate synthase/0.449
1tduCB3Thymidylate synthase/0.448
4gevCB3Thymidylate synthase/0.442