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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fj2QSO17beta-hydroxysteroid dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fj2QSO17beta-hydroxysteroid dehydrogenase/1.000
3qwiCUE17beta-hydroxysteroid dehydrogenase/0.650
4fj0HHF17beta-hydroxysteroid dehydrogenase/0.599
4fj1GEN17beta-hydroxysteroid dehydrogenase/0.577
3qwhKMP17beta-hydroxysteroid dehydrogenase/0.555
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3b6zCO7Enoyl reductase LovC10.440