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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fcq2N6Heat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fcq2N6Heat shock protein HSP 90-alpha/1.000
2vci2GJHeat shock protein HSP 90-alpha/0.671
2wi5ZZ5Heat shock protein HSP 90-alpha/0.608
2vcj2EQHeat shock protein HSP 90-alpha/0.606
2bsmBSMHeat shock protein HSP 90-alpha/0.582
2yi66QMHeat shock protein HSP 90-alpha/0.568
2yecXQ0Heat shock protein HSP 90-alpha/0.548
2wi1ZZ2Heat shock protein HSP 90-alpha/0.540
4eftEFTHeat shock protein HSP 90-alpha/0.537
2ccu2D9Heat shock protein HSP 90-alpha/0.533
2uwd2GGHeat shock protein HSP 90-alpha/0.531
4egh0OYHeat shock protein HSP 90-alpha/0.516
2ye42FYHeat shock protein HSP 90-alpha/0.493
4bqg50QHeat shock protein HSP 90-alpha/0.490
3q5lKX2Heat shock protein 83-1/0.482
4awq592Heat shock protein HSP 90-alpha/0.478
3r4oFU3Heat shock protein HSP 90-alpha/0.463
2werRDCATP-dependent molecular chaperone HSP82/0.452
2yjwYJWHeat shock protein HSP 90-alpha/0.452
1yc34BCHeat shock protein HSP 90-alpha/0.449
3adaNADSubunit alpha of sarocosine oxidase/0.447
3ft5MO8Heat shock protein HSP 90-alpha/0.441