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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ehtADP2-hydroxyisocaproyl-CoA dehydratase activator

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ehtADP2-hydroxyisocaproyl-CoA dehydratase activator/1.000
4ehuANP2-hydroxyisocaproyl-CoA dehydratase activator/0.625
4a2aATPCell division protein FtsA/0.454
1huxADPActivator of (R)-2-hydroxyglutaryl-CoA dehydratase/0.453
3dawATPActin, alpha skeletal muscle/0.443
1g4tFTPThiamine-phosphate synthase/0.440
1s22ATPActin, alpha skeletal muscle/0.440
4cbxATPActin-2/0.440
4eqrFADCoenzyme A disulfide reductase/0.440