sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4e5w | 0NT | Tyrosine-protein kinase JAK1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4e5w | 0NT | Tyrosine-protein kinase JAK1 | / | 1.000 | |
| 4ehz | JAK | Tyrosine-protein kinase JAK1 | / | 0.542 | |
| 4e6d | 0NU | Tyrosine-protein kinase JAK2 | / | 0.531 | |
| 4fk6 | 0UJ | Tyrosine-protein kinase JAK1 | / | 0.531 | |
| 4e4n | 0NL | Tyrosine-protein kinase JAK1 | / | 0.518 | |
| 4ivb | 1J5 | Tyrosine-protein kinase JAK1 | / | 0.512 | |
| 4f08 | 1RS | Tyrosine-protein kinase JAK2 | / | 0.508 | |
| 4i5c | C5I | Tyrosine-protein kinase JAK1 | / | 0.494 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.490 | |
| 4ei4 | 0Q2 | Tyrosine-protein kinase JAK1 | / | 0.479 | |
| 3rak | 03Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.465 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.460 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 4e6q | 0NV | Tyrosine-protein kinase JAK2 | / | 0.455 | |
| 3ezv | EZV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 4ivc | 1J6 | Tyrosine-protein kinase JAK1 | / | 0.451 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1qmz | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2vv9 | IM9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3rkb | 12Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.447 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 4hge | 15V | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3s1h | 56Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4k77 | 1Q4 | Tyrosine-protein kinase JAK1 | / | 0.443 | |
| 2uzd | C85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.442 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.442 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4bgh | 3I6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 |