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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bdrKAIGlutamate receptor ionotropic, kainate 2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bdrKAIGlutamate receptor ionotropic, kainate 2/1.000
2xxvKAIGlutamate receptor ionotropic, kainate 2/0.651
4bdoKAIGlutamate receptor ionotropic, kainate 2/0.570
2wkyIBCGlutamate receptor ionotropic, kainate 1/0.565
2xxyKAIGlutamate receptor ionotropic, kainate 2/0.563
3c36KAIGlutamate receptor ionotropic, kainate 1/0.559
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.551
3c34KAIGlutamate receptor ionotropic, kainate 1/0.549
4f3gKAIGlutamate receptor 3/0.530
1lbbKAIGlutamate receptor 2/0.497
1fw0KAIGlutamate receptor 2/0.496
4h8i11WGlutamate receptor ionotropic, kainate 2/0.487
4f31KAIGlutamate receptor 3/0.486
4f1yCNIGlutamate receptor 3/0.468
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.452
1mewXMPInosine-5'-monophosphate dehydrogenase/0.451
3cppCAMCamphor 5-monooxygenase1.14.15.10.444
1ftlDNQGlutamate receptor 2/0.443
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2yac937Serine/threonine-protein kinase PLK12.7.11.210.440
3bgiSAHThiopurine S-methyltransferase2.1.1.670.440