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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b0gVEKAurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4b0gVEKAurora kinase A2.7.11.11.000
4c3pACPAurora kinase A2.7.11.10.489
4o0uADNAurora kinase A2.7.11.10.488
3k5uPFQAurora kinase A2.7.11.10.483
2wqeADPAurora kinase A2.7.11.10.476
5l8lADPAurora kinase A2.7.11.10.470
2c6eHPMAurora kinase A2.7.11.10.469
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.457
3efwAK8Aurora kinase A2.7.11.10.456
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.456
4jbqVX6Aurora kinase A2.7.11.10.456
3vs1VSATyrosine-protein kinase HCK2.7.10.20.455
3abaFLICytochrome P450/0.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.440