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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ap7F47Hepatocyte growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ap7F47Hepatocyte growth factor receptor2.7.10.11.000
2wgjVGHHepatocyte growth factor receptor2.7.10.10.623
3zxzKRWHepatocyte growth factor receptor2.7.10.10.604
3zze6XPHepatocyte growth factor receptor2.7.10.10.600
4gg70J8Hepatocyte growth factor receptor2.7.10.10.589
4deg0JJHepatocyte growth factor receptor2.7.10.10.581
3a4pDFQHepatocyte growth factor receptor2.7.10.10.578
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.514
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.511
5cwa0GAAnthranilate synthase component 14.1.3.270.456
3zbx6XEHepatocyte growth factor receptor2.7.10.10.448
4kb81QOCasein kinase I isoform delta2.7.11.10.444
3vetADPnebramycin 5' synthase6.1.2.20.442