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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zsi52PMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zsi52PMitogen-activated protein kinase 14/1.000
2gtnLIEMitogen-activated protein kinase 14/0.604
3iw6PP0Mitogen-activated protein kinase 14/0.492
3gc9B45Mitogen-activated protein kinase 112.7.11.240.484
1pmn984Mitogen-activated protein kinase 102.7.11.240.480
4tuvCPZCytochrome P450 1191.140.477
3uvqFS8Mitogen-activated protein kinase 14/0.464
2znnS44Peroxisome proliferator-activated receptor alpha/0.463
2vzmNRBCytochrome P450 monooxygenase PikC/0.461
2c7xNRBCytochrome P450 monooxygenase PikC/0.457
2gtmLIDMitogen-activated protein kinase 14/0.457
3adaNADSubunit alpha of sarocosine oxidase/0.457
3kf7L9GMitogen-activated protein kinase 14/0.457
3ttiKBIMitogen-activated protein kinase 102.7.11.240.453
2ca0PXICytochrome P450 monooxygenase PikC/0.452
2ghmLICMitogen-activated protein kinase 14/0.452
4aacAAVMitogen-activated protein kinase 14/0.452
5itzLOCTubulin beta-2B chain/0.451
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
3iw7IPKMitogen-activated protein kinase 14/0.447
4nb6444Nuclear receptor ROR-gamma/0.446
3hp552PMitogen-activated protein kinase 14/0.443
4fkpLS5Cyclin-dependent kinase 22.7.11.220.443
1k6tXN1Gag-Pol polyprotein3.4.23.160.442
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.441
2r0pK2CPutative FAD-monooxygenase/0.441
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.441
1ot7IU5Bile acid receptor/0.440
2nnhREACytochrome P450 2C8/0.440
2om9AJAPeroxisome proliferator-activated receptor gamma/0.440
2q59240Peroxisome proliferator-activated receptor gamma/0.440
4eh70OOMitogen-activated protein kinase 14/0.440