sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 1.000 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.629 | |
| 4nif | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.500 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.490 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.474 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.465 | |
| 2ijm | ATP | Focal adhesion kinase 1 | 2.7.10.2 | 0.464 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.459 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.456 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.454 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.450 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.449 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1ckp | PVB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.447 | |
| 1gqt | ACP | Ribokinase | / | 0.446 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.444 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.444 | |
| 4a4q | UX9 | Pol protein | / | 0.442 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 |