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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vv0KH3Histone-lysine N-methyltransferase SETD72.1.1.43

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vv0KH3Histone-lysine N-methyltransferase SETD72.1.1.431.000
4e470N6Histone-lysine N-methyltransferase SETD72.1.1.430.578
3vuzK15Histone-lysine N-methyltransferase SETD72.1.1.430.573
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.430.564
1n6cSAMHistone-lysine N-methyltransferase SETD72.1.1.430.541