sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	Histone-lysine N-methyltransferase SETD7
ID:	SETD7_HUMAN
AC:	Q8WTS6
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	2.1.1.43

---

Chains:

Chain Name:	Percentage of Residues within binding site
A	100 %

---

Ligand binding site composition:

B-Factor:	57.887
Number of residues:	33
Including
Standard Amino Acids:	32
Non Standard Amino Acids:	0
Water Molecules:	1
Cofactors:
Metals:

---

Cavity properties

Ligandability	Volume (Å3)
0.251	627.750

% Hydrophobic	% Polar
28.49	71.51
According to VolSite

HET Code:	K15
Formula:	C20H34N7O5
Molecular weight:	452.528 g/mol
DrugBank ID:	-
Buried Surface Area:	61.59 %
Polar Surface area:	191.52 Å2

Number of
H-Bond Acceptors:	9
H-Bond Donors:	5
Rings:	3
Aromatic rings:	2
Anionic atoms:	1
Cationic atoms:	2
Rule of Five Violation:	1
Rotatable Bonds:	12

---

Mass center Coordinates

X	Y	Z
-38.7489	0.630125	-20.8114

• 2D View
• 3D View