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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vs3VSETyrosine-protein kinase HCK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vs3VSETyrosine-protein kinase HCK2.7.10.21.000
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.592
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.586
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.567
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.561
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.557
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.549
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.545
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.514
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.501
3vs1VSATyrosine-protein kinase HCK2.7.10.20.501
3w2sW2REpidermal growth factor receptor2.7.10.10.501
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.482
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.479
3poz03PEpidermal growth factor receptor2.7.10.10.475
4y95746Tyrosine-protein kinase/0.475
4y93746Tyrosine-protein kinase/0.468
3w33W19Epidermal growth factor receptor2.7.10.10.467
5eg3ACPFibroblast growth factor receptor 2/0.463
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.461
4id71G0Activated CDC42 kinase 1/0.454
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.451
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.443
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.443
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.443